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AP-III-a4 hydrochloride

CAS No. 2070014-95-6

AP-III-a4 hydrochloride ( ENOblock hydrochloride )

Catalog No. M25058 CAS No. 2070014-95-6

AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AP-III-a4 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic.
  • Description
    AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic.AP-III-a4 (ENOblock) (0-10 μM; 24 h) inhibits HCT116 cell viability in a dose-dependent manner.AP-III-a4 directly binds to enolase and inhibits its activity.AP-III-a4 (0-10 μM; 24 or 48 h) inhibits cancer cell migration and invasion, induces cancer cell apoptosis.AP-III-a4 (10 μM; 24 h) can induce glucose uptake and inhibit phosphoenolpyruvate carboxykinase (PEPCK) expression in hepatocytes and kidney cells.
  • Synonyms
    ENOblock hydrochloride
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    IC50: 0.576 uM (enolase)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2070014-95-6
  • Formula Weight
    631.2
  • Molecular Formula
    C31H44ClFN8O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Da-Woon Jung, et al. A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes.ACS Chem. Biol., 2013, 8 (6), pp 1271–1282 [Content Brief]
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